ACRIFLAVINE HYDROCHLORIDE

PRODUCT IDENTIFICATION
CAS NO 8048-52-0 (Acriflavine)
69235-50-3 (Acriflavine HCl)

ACRIFLAVINE HYDROCHLORIDE

EINECS NO.  
FORMULA C13H11N3··C14H15N3
MOL WT. 209.25· 225.29

H.S. CODE

 2933.99.4200

TOXICITY

  
SYNONYMS Vetaflavin; Xanthacridinum; Zoriflavin;
Flavacridinum hydrochloricum; Flavine; Flavinetten; Flavioform; Flavipin; Glyco-flavine; Gonacin; Gonacrine; Isravin; Mediflavin; Panflavin; Pantonsiletten; Tolivalin; Angiflan; Assiflavine; Bialflavina; Bioacridin; Bovoflavin; Buroflavin; Choliflavin; Mixture(3,6-diaminoacridine, 3,6-diamino-10-methylacridinium chloride); Mixture(3,6-diamino-10-methylacridinium chloride, 3,6-acridinediamine); Mixture(2,8-diamino-10-methylacridinium chloride, 2,8-diaminoacridine); Euflavine; Trypaflavine Neutral;

SMILES

c12c([n+](c3cc(N)ccc3c1)C)cc(N)cc2.c12c(nc3cc(N)ccc3c1)cc (N)cc 2.[ClH-]

CLASSIFICATION

Antiseptic, Fluorescent Dye, Indicator

EXTRA NOTES

EPA Pesticide Chemical Code 000501
Overall Carcinogenic Evaluation: Group 3
3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-acridinediamine. Fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication. [MeSH]
Other RN: 8018-07-3, 8063-24-9, 50922-89-9, 51367-34-1

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE orange to brown powder
MELTING POINT 260 C
BOILING POINT

 

SPECIFIC GRAVITY

250 (g/l)

SOLUBILITY IN WATER Slightly soluble

SOLVENT SOLUBILITY

 Insoluble in ether, chloroform, and fixed oils
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

AUTOIGNITION

 

NFPA RATINGS  
FLASH POINT

 

STABILITY

Stable under ordinary conditions. Light sensitive.

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Acriflavine

Wikipedia Linking - Acriflavine

Google Scholar Search - Acriflavine

U.S. National Library of Medicine - Acriflavine

PubChem Compound Summary - Acriflavine

Drug Bank -  Acriflavine

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Acriflavine

http://www.ncbi.nlm.nih.gov/ -  Acriflavine

Material Safety Data Sheet - Acriflavine

EPA - Substance Registry Services - Acriflavine

Local:
Acridine is a C13N tricycle compound comprising two benzene rings joined side by side by pyridine skeleton, which is structurally related to anthracene. The central CH group is replaced by nitrogen. Acridine and its derivatives are basic substances for the production of dyes. They are also used as a starting material for the production of some drugs. Acridine is used for vital and supravital staining for the detection of nucleic acids, differentiation of DNA and RNA, and detection of malignant cells. Acridine Orange (3,6-dimethylaminoacridine) is a nucleic acid-selective metachromatic stain useful for cell cycle determination.

Acridine can be obtained by extraction from coal tar and there are several synthetic methods are known (e.g. condensation of diphenylamine with carboxylic acid or chloroform. cyclisation of N-phenylanthranilic acid or 2-(phenylamino)benzoic acid with phosphoric acid, and Lehmstedt-Tanasescu reaction). Acridine and its homologues have antiseptic properties. They bind to DNA and RNA and cause the reversible inclusion of nucleic acids. Proflavine (3,6-diaminoacridine) and acriflavine ( the mixture of 3,6-diaminoacridine chloride and 3,6-diamino-10-methylacridinium chloride) are examples used as an antiseptic agent. Acriflavine is a fluorescent dye used as a biological stain and as a local antiseptic agent for the skin and mucous membranes. It is known to inhibit mitochondriogenesis. Both acriflavin and proflavin having dibenzopyridine structure are used in the synthesis dyes and drugs.

Molecular compounds of Proflavine

Product

CAS RN
Chromoflavine 86-40-8
Acridine Yellow 92-26-2
Proflavine 92-62-6
Ethacridine 442-16-0
Benzoflavine 477-74-7
Proflavine dihydrochloride 531-73-7
Proflavine sulfate 553-30-0
3,9-Diaminoacridine 951-80-4
Proflavine hydrochloride 952-23-8
Proflavine hemisulfate 1811-28-5
Ethacridine lactate 1837-57-6
Diflavine 3407-94-1
Trypaflavine hydrochloride 6034-59-9
3,6-Diaminoacridine hydrochloride 7459-75-8
Xanthacridinum 8048-52-0
Acriflavine dihydrochloride 8063-24-9
Tetramethylacriflavine 20195-94-2
2,9-Diaminoacridine 23043-62-1
1,9-Diaminoacridine 23043-60-9
2,7-Diaminoacridine 23043-63-2
2,7-Di-tert-butyl proflavine 33244-11-0
3,8-Diaminoacridine 40504-84-5
3,5-Diaminoacridine 40505-25-7
2,7-Diaminoacridine hydrochloride 64046-84-0
Acriflavine 65589-70-0
Acriflavine hydrochloride 69235-50-3
Iodoproflavine 74165-93-8
N-Methylproflavine 101952-51-6
N-Propylproflavine 101952-43-6
N-Butylproflavine 101952-50-5
3-Acetamido-5-iodoproflavine 121284-42-2
SALES SPECIFICATION

APPEARANCE

 orange to brown powder

DYES CONTENT

90.0% min
LOSS ON DRYING 7.0% min
TRANSPORTATION
PACKING

 

HAZARD CLASS 9 (Packing Group: III)
UN NO. 3077
SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Skin irritation. Eye irritation. Specific target organ toxicity - single exposure. Acute aquatic toxicity. Hazard statements: Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Toxic to aquatic life.

GHS

 

SIGNAL WORD

Warning

PICTOGRAMS

HAZARD STATEMENTS

H302-H315-H319-H335-H401

P STATEMENTS

P261-P305 + P351 + P338

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

22-36/37/38-50

SAFETY PHRASES

26-36/37/39-61

PRICE INFORMATION